In this review article, we aim at analysing the role of stress in addiction and relapse.In order to do so, we first offer a summary of the findings from affective neuroscience trying to understand compulsive reward-seeking behaviours.These behaviours are characterised by an imbalance between the considerable amount of effort an individual is cock-i
Long-term experimental evolution reveals purifying selection on piRNA-mediated control of transposable element expression
Abstract Background Transposable elements (TEs) are an almost universal constituent of eukaryotic genomes.In animals, Piwi-interacting small RNAs (piRNAs) and repressive chromatin often play crucial roles in preventing TE transcription and thus restricting TE activity.Nevertheless, TE content varies widely across eukaryotes and the dynamics of TE a
Biological properties of soils of former forest fires in Samosir Regency of North Sumatera
A study that was aimed to identify the impact of forest fires on the biological properties of soils was carried out at former forest fire areas in Samosir Regency of North Sumatera.Soil samples were collected Road Studs from former forest fire areas of 2014, 2013, 2012, 2011, 2010.The composite soil samples were collected systematically using diago
Reversal of the Halo Effect: Prolonged Participation in Comprehensive Care for Joint Replacement Negatively Impacts Revision Metrics
Background: The downstream regional effect of the Comprehensive Care for Joint Replacement (CJR) program on care pathway-adjacent patients, including revision arthroplasty patients, is poorly understood.Prior studies have demonstrated that care pathways targeting primary total joint arthroplasty may produce a halo effect, impacting more complex pat